• Home
  • About
  • Team
  • Articles
  • Contact

A Soluble Tau Fragment Generated by Caspase-2 Is Associated with Dementia in Lewy Body Disease

by Myriel Team | Jun 5, 2026 | Human Biomarkers

Smith BR, Nelson KM, Kemper LJ, Leinonen-Wright K, Petersen A, Keene CD, Ashe KH. A Soluble Tau Fragment Generated by Caspase-2 Is Associated with Dementia in Lewy Body Disease. Acta Neuropathologica Communications. 2019;7:1-9. PMID: 31362787. DOI:...

A Soluble Truncated Tau Species Related to Cognitive Dysfunction and Caspase-2 Is Elevated in the Brain of Huntington’s Disease Patients

by Myriel Team | Jun 4, 2026 | Human Biomarkers

Liu P, Smith BR, Huang ES, Mahesh A, Vonsattel JPG, Petersen AJ, Gomez-Pastor R, Ashe KH. A Soluble Truncated Tau Species Related to Cognitive Dysfunction and Caspase-2 Is Elevated in the Brain of Huntington’s Disease Patients. Acta Neuropathologica...

A Soluble Truncated Tau Species Related to Cognitive Dysfunction Is Elevated in the Brain of Cognitively Impaired Human Individuals

by Myriel Team | Jun 3, 2026 | Human Biomarkers

Liu P, Smith BR, Montonye ML, Higgins L, Guerrero CR, Markowski TW, Zhao X, Petersen AJ, Knopman DS, Petersen RC, Ashe KH. A Soluble Truncated Tau Species Related to Cognitive Dysfunction Is Elevated in the Brain of Cognitively Impaired Human Individuals. Scientific...

Caspase-2 mRNA Levels Are Not Elevated in Mild Cognitive Impairment, Alzheimer’s Disease, Huntington’s Disease, or Lewy Body Dementia

by Myriel Team | Jun 2, 2026 | Human Biomarkers

Hlynialuk C, Kemper L, Leinonen-Wright K, Petersen RC, Ashe KH, Smith BR. Caspase-2 mRNA Levels Are Not Elevated in Mild Cognitive Impairment, Alzheimer’s Disease, Huntington’s Disease, or Lewy Body Dementia. PLoS One. 2022;17(9):e0274784. PMID: 36197950....

Recent Posts

  • Targeting Caspase-2 for the Treatment of Dementia.
  • Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
  • Caspase-2 Cleavage of Tau Reversibly Impairs Memory
  • Phosphorylation in Two Discrete Tau Domains Regulates a Stepwise Process Leading to Postsynaptic Dysfunction
  • Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia

Myriel Inc.
1000 Westgate Drive,
Suite 9150-E
Saint Paul MN 55114
Email Us

About

Team

Contact

Copyright 2026 Myriel Inc. | All Rights Reserved