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An Electrophilic Fragment Screening for the Development of Small Molecules Targeting Caspase-2

by Myriel Team | Jul 26, 2024 | Article

Cuellar, M. E.; Yang, M.; Karavadhi, S.; Zhang, Y.-Q.; Zhu, H.; Sun, H.; Shen, M.; Hall, M. D.; Patnaik, S.; Ashe, K. H.; Walters, M. A.; Pockes, S. An Electrophilic Fragment Screening for the Development of Small Molecules Targeting Caspase-2. Eur. J. Med. Chem....

Targeting Caspase-2 Interactions with Tau in Alzheimer’s Disease and Related Dementias

by Myriel Team | Jul 26, 2024 | Article

Cuellar, M. E.; Yang, M.; Karavadhi, S.; Zhang, Y.-Q.; Zhu, H.; Sun, H.; Shen, M.; Hall, M. D.; Patnaik, S.; Ashe, K. H.; Walters, M. A.; Pockes, S. An Electrophilic Fragment Screening for the Development of Small Molecules Targeting Caspase-2. Eur. J. Med. Chem....

Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy

by Myriel Team | Jun 12, 2024 | Article

Singh, G.; Liu, P.; Yao, K. R.; Strasser, J. M.; Hlynialuk, C.; Leinonen-Wright, K.; Teravskis, P. J.; Choquette, J. M.; Ikramuddin, J.; Bresinsky, M.; Nelson, K. M.; Liao, D.; Ashe, K. H.; Walters, M. A.; Pockes, S. Caspase-2 Inhibitor Blocks Tau Truncation and...

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